Cyclopiazonic acid

- Overview
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    Background
    
    Cyclopiazonic acid is a neurotoxic secondary metabolite produced by A. flavus and is a nanomolar inhibitor of endoplasmic reticulum calcium ATPase (Ca2+ATPase; SERCA). Cyclobenzoic acid does not inhibit many other types of membrane-bound ATPase, it can effectively inhibit SERCA in intact tissues, smooth muscle and endothelium, and isolated cells[1,2]. It is an effective inducer of plant cell death[3].
    
    [1]. Mumtaz S, Burdyga G, Borisova L, et al. The mechanism of agonist induced Ca2+ signalling in intact endothelial cells studied confocally in in situ arteries. Cell Calcium, 2011, 49(1): 66-77.
    [2]. Berra-Romani R, Raqeeb A, Torres-Jácome J, et al. The mechanism of injury-induced intracellular calcium concentration oscillations in the endothelium of excised rat aorta. Journal of Vascular Research, 2012, 49(1): 65-76.
    [3]. Chalivendra S C, et al. Cyclopiazonic Acid Is a Pathogenicity Factor for Aspergillus flavus and a Promising Target for Screening Germplasm for Ear Rot Resistance. Mol Plant Microbe Interact, 2017, 30(5): 361-373.
- Properties
  - Alternative Name
    
    (6aS,11aR,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-6a,7,11a,11b-tetrahydro-2H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9(6H)-one
    
    CAS Number
    
    18172-33-3
    
    Molecular Formula
    
    C20H20N2O3
    
    Molecular Weight
    
    336.39
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    Purity ≥95.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

Cyclopiazonic acid

Background

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