Cyclic di-GMP

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Cyclic-di-GMP is a STING agonist and a ubiquitous second messenger that regulates biofilm formation, motility, and virulence in diverse bacterial species.
    References :
    [1]. Nakamura T, et al. Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J Control Release. 2015 Oct 28;216:149-57.
    [2]. Burdette DL, et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature. 2011 Sep 25;478(7370):515-8.
- Properties
  - Categories
    
    second messenger
    
    Alternative Name
    
    9,9'-((2R,3R,3aS,7aR,9R,10R,10aS,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidodecahydrodifuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl)bis(2-amino-1H-purin-6(9H)-one)
    
    CAS Number
    
    61093-23-0
    
    Molecular Formula
    
    C20H24N10O14P2
    
    Molecular Weight
    
    690.41
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in DMSO; insoluble in EtOH; ≥20.85 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O=C1NC(N)=NC2=C1N=CN2[[email protected]](O[[email protected]@]([[email protected]@]3([H])OP(O)(OC[[email protected]]([[email protected]@]4([H])OP5(O)=O)(O[[email protected]@H](N6C(N=C(N)NC7=O)=C7N=C6)[[email protected]@H]4O)[H])=O)(CO5)[H])[[email protected]@H]3O
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

Cyclic di-GMP

Background

Documents

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