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CU CPT 4a

CU CPT 4a

Catalog Number:
L002371232APE
Mfr. No.:
APE-B5752
Price:
$328
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      • Overview

        • Please contact us at for specific academic pricing.

          Background

          CU CPT 4a is a selective TLR3 inhibitor with IC50 of 3.44 μM in RAW 264.7 cells. It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cells. It reduces the mortality of crypt cells in mice and reduces gastrointestinal syndrome.

          [1]. Cheng K, Wang X, Yin H. Small-Molecule Inhibitors of the TLR3/dsRNA Complex. Journal of the American Chemical Society, 2011, 133(11): 3764-3767.
          [2]. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nature Communications, 2014, 5.

      • Properties
        • Alternative Name
          (R,Z)-2-(((3-chloro-6-fluorobenzo[b]thiophen-2-yl)(hydroxy)methylene)amino)-3-phenylpropanoic acid
          CAS Number
          1279713-77-7
          Molecular Formula
          C18H13ClFNO3S
          Molecular Weight
          377.82
          Appearance
          White solid
          Purity
          98.00%
          Solubility
          <37.78mg/ml in DMSO
          Storage
          Store at -20°C

          * For Research Use Only

      • Reference

        • 1. Cong Li, Jinxian Huang, et al. "Pyridoxal-5'-Phosphate Promotes Immunomodulatory Function of Adipose-Derived Mesenchymal Stem Cells through Indoleamine 2,3-Dioxygenase-1 and TLR4/NF-κB Pathway." Stem Cells International. Volume 2019, Article ID 3121246, 15 pages

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