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Overview
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CSF2RA Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 324 amino acids (20-320 a.a) and having a molecular mass of 37.2kDa. CSF2RA is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. GM-CSFReceptor Alpha (CSF2RA) is the alpha subunit of the heterodimeric receptor forcolony stimulating factor 2, a cytokine which controls the production,differentiation, and function of granulocytes and macrophages. CSFR2 is also amember of the cytokine family of receptors. In addition, this gene is found inthe pseudoautosomal region (PAR) of the X and Y chromosomes. Multipletranscript variants encoding various isoforms have been found for this gene, whilesome of the isoforms being membrane-bound and others being soluble. Diseasesassociated with CSF2RA include surfactant metabolism dysfunction, pulmonary 4,and csf2ra-related pulmonary surfactant metabolism dysfunction.
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Overview