Name: (±)-CPSI 1306
Price: 536.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    (±) -CPSI 1306 is an inhibitor of macrophage inhibitory factor (MIF) [1]. MIF is a proinflammatory cytokine and is an important regulation element of innate immunity. MIF plays an important role in the pathogenesis of many autoimmune inflammatory diseases [1]. In Skh-1 hairless mice with UVB exposure, CPSI 1306 reduced myeloperoxidase (MPO) activity and skin thickness and increased p53 expression and keratinocyte apoptosis. In mice with squamous carcinogenesis, CPSI-1306 slowed tumor growth and reduced p53 foci in non-tumor skin [1]. In ICR mice with streptozotocin (STZ) -induced non-insulin-dependent diabetes mellitus (NIDDM), CPSI 1306 significantly decreased blood glucose levels and reduced the levels of IL-6 and TNF-ɑ, the proinflammatory cytokines. These results suggested that MIF was involved in the pathogenesis of NIDDM [2]. In wild-type C57Bl/6 mice immunized with myelin oligodendrocyte glycoprotein (MOG35–55), which induced experimental autoimmune encephalomyelitis (EAE), CPSI-1306 (1 mg/kg) reduced the inflammation and reduced the severity of disease [3].
    
    [1]. Nagarajan P, Tober KL, Riggenbach JA, et al. MIF antagonist (CPSI-1306) protects against UVB-induced squamous cell carcinoma. Mol Cancer Res, 2014, 12(9): 1292-1302.
    [2]. Sanchez-Zamora Y, Terrazas LI, Vilches-Flores A, et al. Macrophage migration inhibitory factor is a therapeutic target in treatment of non-insulin-dependent diabetes mellitus. FASEB J, 2010, 24(7): 2583-2590.
    [3]. Kithcart AP, Cox GM, Sielecki T, et al. A small-molecule inhibitor of macrophage migration inhibitory factor for the treatment of inflammatory disease. FASEB J, 2010, 24(11): 4459-4466.
- Properties
  - Alternative Name
    
    (S)-2-(3-(2,4-difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethanone
    
    CAS Number
    
    1309793-47-2
    
    Molecular Formula
    
    C15H16F2N2O3
    
    Molecular Weight
    
    310.3
    
    Appearance
    
    White solid
    
    Purity
    
    98.00%
    
    Solubility
    
    <31.03mg/ml in DMSO; insoluble in ethanol
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

(±)-CPSI 1306

(±)-CPSI 1306

Background

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