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Overview
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Potent and selective Y5 agonist.
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] – hPancreatic Polypeptide is a potent and selective peptide agonist for the neuropeptide Y Y5 receptor , with IC50 values for inhibition of neuropeptide Y binding to human Y5, Y1, Y2 and Y4 receptors of 0.24, 530, > 500, and 51 nM respectively, and a Ki at Y5 of 0.1 – 0.15 nM. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] – hPancreatic Polypeptide stimulates food intake in vivo.
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Overview