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Overview
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Background
Cytochrome c oxidase 17 (COX17) is a nuclear gene encoding an assembly protein necessary for proper COX apoenzyme-dependent mitochondrial respiration. The mammalian COX apoenzyme is a heteromer consisting of three mitochondrial genes that encode catalytic subunits and several nuclear genes that encode structural subunits. COX17 influences the recruitment of copper to the mitochondria for incorporation into the COX apoenzyme.
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Overview