COA7 Polyclonal Antibody

COA7 Polyclonal Antibody

Catalog Number:
A001508036RED
Mfr. No.:
RD252496A
Price:
$253
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      • Overview
        • Calculated MW: 26 kDa
          Observed MW: Refer to figures
          Gene Accession: BC015313

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          Background

          The cytochrome c oxidase (COX) family of proteins function as the final electron donor in the respiratory chain to drive a proton gradient across the inner mitochondrial membrane, ultimately resulting in the production of water. COA7 (cytochrome c oxidase assembly factor 7), also known as RESA1, SELRC1 or C1orf163, is a 231 amino acid mitochondrial protein that belongs to the hcp beta-lactamase family. Consisting of five Sel1-like repeats, COA7 may be associated with respiratory chain assembly. COA7 is encoded by a gene located on human chromosome 1p32.3. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene, which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration.

      • Properties
        • Host
          rabbit
          Antibody Type
          polyclonal
          Isotype
          IgG
          Reactivity
          human; mouse
          Immunogen
          Full length fusion protein
          Purification
          Antigen affinity purification
          Conjugate
          Unconjugated
          Formulation
          PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
          Storage
          Store at -20°C. Avoid freeze-thaw cycles.
          Concentration
          0.9 mg/mL
          Antigen
          beta-lactamase hcp-like protein, C1orf163, Chromosome 1 open reading frame 163, FLJ12439, Hcp beta lactamase like protein C1orf163, Hypothetical protein LOC65260, RESA1, Sel1 repeat containing 1, sel1 repeat-containing protein 1 (UniProt:Q96BR5)

          * For reference only.

      • Applications
        • Application
          WB; IHC; ELISA
        • Application Dilutions
          WB 1:500-1:2000
          IHC 1:40-1:200
          ELISA 1:5000-1:10000

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