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CNX-2006

CNX-2006

Catalog Number:
L002370458APE
Mfr. No.:
APE-B3227
Price:
$276
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      • Overview

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          Background

          CNX-2006, a structural analog of CO-1686, is a selective and irreversible inhibitor of mutant-EGFR with IC50 value of < 20 nM.
          The epidermal growth factor receptor (EGFR) is the cell-surface receptor for epidermal growth factor and plays an important role in tumor invasion and cancer cell proliferation.
          CNX-2006 is a novel and irreversible mutant-selective EGFR inhibitor with very weak inhibition of wild-type EGFR. In non-small cell lung cancer (NSCLC) models expressing mutant EGFR-T790M, CNX-2006 inhibited EGFR signaling. CNX-2006 acquired resistance which was drove by NF-κB. So NF-κB activation might replace the EGFR signaling. These results suggested that inhibition of NF-κB pathway was a promising therapy method for patients who progressed after treatment with mutant-selective EGFR inhibitors [1].

      • Properties
        • Alternative Name
          N-(3-((2-((4-((1-(2-fluoroethyl)azetidin-3-yl)amino)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide
          CAS Number
          1375465-09-0
          Molecular Formula
          C26H27F4N7O2
          Molecular Weight
          545.53
          Appearance
          A solid
          Purity
          99.08%
          Solubility
          ≥27.3 mg/mL in DMSO
          Storage
          Store at -20°C

          * For Research Use Only

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