CM Bestdex C-25 - Weak Cation Exchange Resins

Ion exchange (IEX) chromatography is a very effective method for separation and purification of biological molecules. The method mainly relies on the interaction between positive and negative charges and uses the nature and difference of the charges carried by different biomolecules under specific conditions to separate. It has the characteristics of high load capacity, good resolution, controllable conditions and easy amplification. It has been widely used in medicine, chemical industry, metallurgy, food and other fields.
The ion exchange resin is composed of three parts:
(1) Cross-linked mesh base frame, which is porous, hydrophilic and chemically stable.
(2) The functional group fixed on the base frame, which is a charged group, determines the nature of the ion exchange chromatography resin.
(3) An ion (called an equilibrium ion) that has an opposite charge to the functional group and can be reversibly bound to the functional group.
CM Bestdex C-25 is a weak cation exchange resin formed by coupling carboxymethyl groups on cross-linked dextran microspheres. It retains the excellent hydrophilicity and pore structure of natural polysaccharide compounds, good compatibility with biologically active molecules, and very low non-specific adsorption. CM Bestdex C-25 is based on Bestdex G-25, which has a very high capacity for small molecular substances and is very suitable for the separation and purification of antibiotics, natural products and other substances. Due to the large variation of the column bed volume of the chromatography resin in different buffers, it is not suitable to be installed as a fixed bed chromatography column.

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