Clarithromycin related compound L, EvoPure®

127253-05-8

C38H70N2O13

762.97

White

-20°C

Spectrum: Clarithromycin is a broad-spectrum antibiotic with bacteriostatic action wide range of Gram-positive and Gram-negative bacteria including anaerobes. It is also effective for Mycoplasma and Mycobacteria.

Microbiology Applications: Clarithromycin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative bacteria. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:Haemophilus influenza 2 µg/mL - 32 µg/mL Streptococcus pneumoniae 0.12 µg/mL – 64 µg/mL
Eukaryotic Cell Culture Applications: Clarithromycin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative bacteria. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include: Haemophilus influenza 2 µg/mL - 32 µg/mL Streptococcus pneumoniae 0.12 µg/mL – 64 µg/mL Our Clarithromycin used in methacrylate-based copolymer films that released the compound (along with doxycycline and rifampicin) for up to 21 days were found to prevent biofilm formation when in an in vitro bioreactor model (Rose et al, 2015).

Cancer Applications: Clarithromycin is involved in autophagy-lysosome pathway. It can inhibit autophagy in myeloma and myeloid leukaemia cells. It inhibits lysosomal function after fusion of the autophagosomes with the lysosomes. Thus, it could be a potential adjuvant where autophagy is used by the tumor as an escape mechanism (Nakamura et al, 2010). The combined treatment of Clarithromycin with the proteasome inhibitor bortezomib enhances cytotoxicity in the breast cancer cell lines MDA-MB-231 and MDA-MB-468. A wild-type murine embryonic fibroblast (MEF) cell line also exhibited enhanced cytotoxicity (Komatsu et al, 2012). Direct antineplastic effects of CAM may depend on the tumor type. Researchers found a direct anti-tumor activity of CAM on lymphoma cells (Ochi et al, 2006) and it directly induced apoptosis in a murine B cell lymphoma cell line (Ohara et al, 2004).