Name: CHIR 99021 trihydrochloride
Price: 212.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    CHIR 99021 trihydrochloride is hydrochloride of CHIR 99021, which inhibits GSK-3α and GSK-3β with IC50 values of 10 nM and 6.7 nM. GSK-3 is a serine/threonine kinase, responsible for phosphorylating either the serine or threonine residues of its substrates. This phosphorylation process is involved in various key biological processes, including gene transcription, protein synthesis, cell signaling, cellular transport, proliferation, apoptosis, intracellular communication and glucose regulation.
    
    1. Ring DB, Johnson KW, Henriksen EJ, et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes, 2003, 52(3): 588-595.
    2. Pandey MK, DeGrado TR. Glycogen synthase kinase-3 (GSK-3)-targeted therapy and imaging. Theranostics, 2016, 6(4): 571-593.
    3. Mussmann R, Geese M, Harder F, et al. Inhibition of GSK3 promotes replication and survival of pancreatic beta cells. Journal of Biological Chemistry, 2007, 282(16): 12030-12037.
- Properties
  - Alternative Name
    
    (Z)-6-((2-((E)-(4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2(1H)-ylidene)amino)ethyl)imino)-1,6-dihydropyridine-3-carbonitrile trihydrochloride
    
    Molecular Formula
    
    C22H18Cl2N8·3HCl
    
    Molecular Weight
    
    574.72
    
    Appearance
    
    Off White solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in EtOH; ≥21.87 mg/mL in DMSO; ≥32.45 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

CHIR 99021 trihydrochloride

CHIR 99021 trihydrochloride

Background

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