CHAPS

- Overview
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    Background
    
    CHAPS is a zwitterionic nondenaturing detergent for solubilizing membrane proteins. CHAPS is often used as a detergent in the solubilization and purification of membrane proteins for several advantageous reasons. CHAPS detergent is non-denaturing to membrane proteins, can solubilize proteins, disaggregate protein-protein interactions and is electrically neutral. CHAPS is also useful in ion exchange chromatography and isoelectric focusing as it is zwitterionic and does not exhibit a net charge between pH 2 to 12. The critical micelle concentration of CHAPS is 6-10mM.
- Properties
  - Categories
    
    Zwitterionic detergent for membrane proteins, nondenaturing
    
    Alternative Name
    
    3-[dimethyl-[3-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]propyl]azaniumyl]propane-1-sulfonate
    
    CAS Number
    
    75621-03-3
    
    Molecular Formula
    
    C32H58N2O7S
    
    Molecular Weight
    
    614.88
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥61.5 mg/mL in H2O; insoluble in EtOH; insoluble in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC(CCC(=O)NCCC[N+](C)(C)CCCS(=O)(=O)[O-])C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

CHAPS

Background

Documents

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