Ceftazidime

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Ceftazidime is categorized as a third-generation cephalosporin which show a broad spectrum of in vitro activity against both Gram-positive and Gram-negative aerobic bacteria, including Pseudomonas aeruginosa (P. aeruginosa). In fact, ceftazidime is by far the most active cephalosporin available against P. aeruginosa in vitro, but it is less active against Staphylococcus aureus (S. aureus) than first and second generation cephalosporins. Also, ceftazidime is particularly active against most Enterobacteriaceae, including β-lactamase-positive strains, since it is highly resistant to hydrolysis induced by β-Iactamases.
    
    1. Richards DM, Brogden RN. Ceftazidime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs, 1985, 29(2): 105-161.
- Properties
  - Categories
    
    A third-generation cephalosporin
    
    Alternative Name
    
    2-(((Z)-((Z)-2-(((6R,7R)-2-carboxy-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl)imino)-2-hydroxy-1-(2-imino-2,3-dihydrothiazol-4-yl)ethylidene)amino)oxy)-2-methylpropanoate
    
    CAS Number
    
    72558-82-8
    
    Molecular Formula
    
    C22H22N6O7S2
    
    Molecular Weight
    
    546.58
    
    Appearance
    
    A solid
    
    Purity
    
    98.22%
    
    Solubility
    
    ≥21.25 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC(C([O-])=O)(O/N=C(\C(O)=N\[[email protected]]([[email protected]]1([H])N2C(C(O)=O)=C(CS1)C[N+]3=CC=CC=C3)([H])C2=O)C(N4)=CSC4=N)C
    
    * For Research Use Only