Cefotetan

- Overview
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    Background
    
    Like β-lactams, cephamycins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactam antibiotics is commonly due to cells containing plasmid encoded β-lactamases, however, many cephamycins are unaffected by this mechanism.
- Properties
  - CAS Number
    
    69712-56-7
    
    Molecular Formula
    
    C17H17N7O8S4
    
    Molecular Weight
    
    575.62
    
    Appearance
    
    White or light-yellow powder
    
    Other Properties
    
    Source: Semi-synthetic
    Water Content (Karl Fischer): ≤ 2.5%
    Assay: (On Dried Basis): 96.0-102.0%
    Residue On Ignition: ≤ 0.1%
    Optical Rotation: +112° to +124°
    Identification: IR
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Cefotetan is a broad-spectrum antibiotic targeting a wide variety of gram-positive and gram-negative bacteria. Like many cephamycins, cefotetan is very effective against anaerobic bacteria such as Bacteroides and Clostridium species.
    
    Microbiology Applications: Cefotetan is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against aerobic and anaerobic gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:Bacteroides fragilis 2 µg/mL – 512 µg/mLClostridium difficile 8 µg/mL - 32 µg/mL.

MSDS

Documents

MSDS-EU

Susceptibility and Resistance Data

Cefotetan

Background

Documents

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