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Overview
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Calculated MW: 91kDa/108kDa/114kDa
Observed MW: 120kDaPlease contact us at for specific academic pricing.
Background
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
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