CD38 hydrolase Activity Fluorometric Assay (TBS2047)

Cluster of Differentiation 38 (CD38) is a multifunctional ectoenzyme expressed in many immune cells including CD4+, CD8+, B lymphocytes, and natural killer cells. CD38 serves as a hydrolase and a nicotinamide adenine dinucleotide (NAD+) cyclase, involved in the metabolism of nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP). The results are the production of Ca2+-mobilizing compounds, such as cyclic ADP ribose (cADPR) and ADP ribose (ADPR). CD38 is used as a marker for poor prognosis in chronic lymphocytic leukemia and multiple myeloma and is an attractive cancer immunotherapy drug target.

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