CCT 031374 hydrobromide

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    CCT 031374 hydrobromide is a selective inhibitor of Wnt/β-catenin signaling pathway [1].
    The Wnt/β-catenin pathway is activated by the binding of Wnt ligand to a complex comprising LRP5/6 and Frizzled (Fz) receptors and then activates transcription factor/β-catenin-dependent transcription [1].
    CCT 031374 hydrobromide is a selective Wnt/β-catenin signaling pathway inhibitor. CCT031374 inhibited BIO-induced β-catenin accumulation in L-cells with IC50 value of 6.1 μM. In HCT116 human colon cancer cell line, CCT031374 inhibited cell proliferation by inducing apoptosis. In mouse L-cells, BIO, a GSK-3 inhibitor, significantly increased total β-catenin levels. While CCT031374 inhibited BIO-induced accumulation of β-catenin in both nuclear and cytosolic. In U2OS GFP-β-catenin human osteosarcoma cells, CCT031374 induced the formation of GFP-β-catenin aggregates. In human neurogenic embryoid bodies, CCT031374 reduced the mRNA levels of endogenous LEF1. Also, CCT031374 inhibited cell growth with GI values of 11.5, 13.9, 13.2, 9.6 and 44 μM in HT29, HCT116, SW480, SNU475 and CCD841Co cancer cell lines, respectively [1].
- Properties
  - Alternative Name
    
    1-([1,1'-biphenyl]-4-yl)-2-(2H-benzo[d]imidazo[1,2-a]imidazol-9(3H)-yl)ethanone hydrobromide
    
    CAS Number
    
    1219184-91-4
    
    Molecular Formula
    
    C23H19N3O·HBr
    
    Molecular Weight
    
    434.33
    
    Appearance
    
    Pale yellow solid
    
    Purity
    
    98.00%
    
    Solubility
    
    <21.72mg/ml in DMSO
    
    Storage
    
    Desiccate at RT
    
    * For Research Use Only

CCT 031374 hydrobromide

Background

We Also Recommend

CYM 50260

CYM 50308

CYM 50358 hydrochloride