CBZ-N-amido-dPEG®₆-acid

CBZ-N-amido-dPEG®6-acid, product number 10066, is a benzyl carbamate (Cbz) N-protected amino-dPEG®-acid that provides a short, single molecular weight discrete PEG (dPEG®) spacer. It can be used in peptide synthesis as well as in many other reactions. In peptide synthesis, removal of the Cbz protecting group is orthogonal to many other protecting groups.

PEGylation
PEGylation refers to the covalent addition of polyethylene glycol (PEG) to a compound or surface. PEGylated compounds include proteins, peptides, dyes or other labels, and small molecule drugs. Increasing a molecule's water solubility is a common reason for PEGylating molecules. Moreover, peptide PEGylation prolongs the in vivo circulation of peptide conjugates by increasing the conjugate's hydrodynamic volume and protecting the peptide from proteolysis. Additionally, PEGylation reduces or eliminates the antigenicity of the conjugated peptide.

Quanta BioDesign makes and sells single molecular weight (i.e., monodispersed) PEG products. Well call our products "discrete PEG" and sell them under the dPEG® trademark. Our dPEG® products provide all of the benefits of traditional, dispersed PEG compounds. However, our dPEG® reagents eliminate the analytical headache that comes from having a complex mixture of conjugates, each with different PEG chain lengths.

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