CBFB Polyclonal Antibody

CBFB Polyclonal Antibody

Catalog Number:
A001508056RED
Mfr. No.:
RD252520A
Price:
$253
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      • Overview
        • Calculated MW: 22 kDa
          Observed MW: Refer to figures
          Gene Accession: BC018509

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          Background

          The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.

      • Properties
        • Host
          rabbit
          Antibody Type
          polyclonal
          Isotype
          IgG
          Reactivity
          human; mouse
          Immunogen
          Full length fusion protein
          Purification
          Antigen affinity purification
          Conjugate
          Unconjugated
          Formulation
          PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
          Storage
          Store at -20°C. Avoid freeze-thaw cycles.
          Concentration
          0.6 mg/mL
          Antigen
          CBF b, CBF beta, CBF-beta, CBFB, CBFbeta, Core binding factor beta subunit, core binding factor subunit beta, Core-binding factor subunit beta, PEA 2, PEA2, PEA2 beta, PEA2-beta, PEA2beta, PEBB, PEBP 2B, PEBP2 beta, PEBP2-beta, PEBP2B, PEBP2beta, Polyomavirus enhancer binding protein 2 beta subunit, Polyomavirus enhancer-binding protein 2 beta subunit, SL3 3 enhancer factor 1 beta subunit, SL3 3 enhancer factor 1 subunit beta, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core binding factor beta subunit, SL3/AKV core-binding factor beta subunit (UniProt:Q13951)

          * For reference only.

      • Applications
        • Application
          WB; IHC; ELISA
        • Application Dilutions
          WB 1:500-1:2000
          IHC 1:30-1:150
          ELISA 1:5000-1:10000

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