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Overview
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Caspase-1 (IL-1β Converting Enzyme, ICE) is the prototypical member of the ICE family of cysteine proteases, also known as caspases (cysteinyl aspartate-specific proteases). Caspase-1 was first identified as a novel protease that generates the proinflammatory cytokine, interleukin-1β by cleaving pro-interleukin-1β. It plays an important role in inflammatory diseases and cancer.
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