Name: Carmustine
Price: 180.00 USD

- Overview
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    Background
    
    Carmustine is a nitrogen mustard β-chloro-nitrosourea compound that is used as an antitumor chemotherapeutic agent[1].
    In rat glial tumor cytosol and intact cells, carmustine (8, 80, and 800 µM) reduces N-acetyltransferase activities for 2-aminofluorene and p-aminobenzoic acid. In rat glioma cells, carmustine reduces the formation of DNA-AF adducts[1].
    Intraperitoneal administration of carmustine 25 mg/kg in rat, which increases liver-to-weight ratio, significantly reduces bile flow, and decreases GSSG and GSH/GSSG values, and mild fibrous edema and monocyte infiltration in the liver of rats[2].
    
    [1].Hung C F. Effects of carmustine and lomustine on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adducts in rat glial tumor cells. Neurochem Res, 2000, 25(6): 845-51.
    [2].Demir A, et al. The effect of trimetazidine on intrahepatic cholestasis caused by carmustine in rats. Hepatol Res, 2001, 20(1): 133-143.
- Properties
  - Categories
    
    cell-cycle phase nonspecific alkylating antineoplastic agent
    
    Alternative Name
    
    (Z)-N,N'-bis(2-chloroethyl)-N-nitrosocarbamimidic acid
    
    CAS Number
    
    154-93-8
    
    Molecular Formula
    
    C5H9Cl2N3O2
    
    Molecular Weight
    
    214.05
    
    Appearance
    
    A solid
    
    Purity
    
    99.54%
    
    Solubility
    
    insoluble in H2O; ≥21.51 mg/mL in DMSO; ≥27.15 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    ClCC/N=C(O)/N(N=O)CCCl
    
    * For Research Use Only