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Overview
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Gene Accession: NP665810
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Background
CACNG5 (Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 5) is a Protein Coding gene. Diseases associated with CACNG5 include Schizophrenia. Among its related pathways are CCR5 Pathway in Macrophages and PEDF Induced Signaling. GO annotations related to this gene include voltage-gated calcium channel activity and ion transmembrane transporter activity. An important paralog of this gene is CACNG7.The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder.
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