Name: C7280948
Price: 180.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    C7280948 is a novel PRMT1 inhibitor with IC50 value of 12.75 μM [1]. Protein arginine methyltransferase 1 (PRMT1) is a histone methyltransferase specific for histone H4. PRMT1 catalyzes the transfer of the methyl group from SAM to the guanidine nitrogen atoms of arginine residues to produce monomethyl arginines (MMA) and asymmetric dimethyl arginines (ADMA) [2]. C7280948 is a novel PRMT1 inhibitor. C7280948 interacts with aromatic residues at the hPRMT1 substrate binding pocket (Tyr 147 and Tyr 160) [1]. C7280948 inhibited hPRMT1 with IC50 value of 26.7 μM [3].
    
    [1]. Heinke R, Spannhoff A, Meier R, et al. Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors. ChemMedChem, 2009, 4(1): 69-77.
    [2]. Itoh Y, Suzuki T, Miyata N. Small-molecular modulators of cancer-associated epigenetic mechanisms. Mol Biosyst, 2013, 9(5): 873-896.
    [3]. Bissinger EM, Heinke R, Spannhoff A, et al. Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg Med Chem, 2011, 19(12): 3717-3731.
- Properties
  - Alternative Name
    
    4-amino-N-phenethylbenzenesulfonamide
    
    CAS Number
    
    587850-67-7
    
    Molecular Formula
    
    C14H16N2O2S
    
    Molecular Weight
    
    276.35
    
    Appearance
    
    A solid
    
    Purity
    
    99.89%
    
    Solubility
    
    insoluble in H2O; insoluble in EtOH; ≥13.9 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

We Also Recommend

Chidamide

$335

Cyclosporin D

$306

Solithromycin

$233

C7280948

C7280948

Background

We Also Recommend

Chidamide

Chidamide

Cyclosporin D

Solithromycin