Name: BWX 46
Price: 446.00 USD

- Overview
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    Background
    
    IC50: 0.5 nM for Y5
    The actions of neuropeptide Y (NPY) are mediated by at least six G-protein coupled receptors denoted as Y1, Y2, Y3, Y4, Y5, and y6. Investigations using receptor selective ligands and receptor knock-out mice show that NPY effects on feeding are mediated by both Y1 and Y5 receptors. BWX 46 is a Y5 receptor selective agonist.
    In vitro: BWX 46 selectively bound Y5 receptors, and inhibited cAMP synthesis by Y5 cells with potencies comparable to that of NPY. In addition, BWX 46 (10 μM) exhibited no significant effect on the cAMP synthesis by Y1, Y2, and Y4 cells. Thus, BWX 46 constitutes the lowest molecular weight Y5 selective agonist reported to date [1].
    In vivo: Intrahypothalamic-injection of 30 and 40 μg of BWX 46 stimulated the food intake by rats in a gradual manner, reaching maximal level 8 h after injection. This response was similar to that exhibited by other Y5 selective agonists, but differed from that of NPY, which exhibited a rapider orexigenic stimulus within 1 h [1].
    Clinical trial: Up to now, BWX 46 is still in the preclinical development stage.
- Properties
  - Categories
    
    NPY Y5 receptor agonist, potent and highly selective
    
    Alternative Name
    
    (2S,5S,8S,11S,14R,17S,20S,Z)-N'1-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-20-((2S,3S)-2-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-14-((5R,8S,11S,14S,17S)-22-amino-5-((S)-2-((S)-4-amino-2-((2S,3S)-2-((S)-2-amino-3-(4-hydro
    
    CAS Number
    
    172997-92-1
    
    Molecular Formula
    
    C116H186N36O28S2
    
    Molecular Weight
    
    2597.07
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; insoluble in EtOH; ≥260.4 mg/mL in DMSO with ultrasonic
    
    Storage
    
    Desiccate at -20°C
    
    SMILES
    
    CCC[[email protected]@](NC([[email protected]](NC([[email protected]](NC([[email protected]](NC([[email protected]](NC([[email protected]](NC([[email protected]](NC([[email protected]](N)([H])CC1=CC=C(O)C=C1)=O)([H])[[email protected]@](CC)([H])C)=O)([H])CC(O)=N)=O)([H])CC(C)C)=O)([H])CSSC[[email protected]@](NC([[email protected]](NC([[email protected]](NC([[email protected]](NC([[email protected]](N)([H])CC2=CC=C(O)C=C2)=O)([H])[[email protected]@](CC)([H])C)=O)([H])CC(N)=O
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

BWX 46

BWX 46

Background

Documents

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