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Overview
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Butanoyl Coenzyme A (Butanoyl-CoA), also known as butyryl-CoA, is a thioester of Coenzyme A that plays a crucial role in fatty acid metabolism and energy production. It is formed as an intermediate during the β-oxidation of fatty acids and serves as a substrate for various enzymes involved in lipid metabolism and biosynthetic pathways. Butanoyl-CoA is important in the synthesis of butyrate, a short-chain fatty acid that is a key energy source for colonocytes and has significant roles in maintaining gut health and modulating inflammatory responses. It also functions as an acyl donor in the elongation and degradation of fatty acids, making it a critical intermediate in cellular metabolism (Vital et al., 2017; Louis & Flint, 2017).
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