ɑ-Butyric Acid-ω-Mercaptopropanamido PEG , 5000 Dalton

A heterobifunctional PEG derivative has a sulfhydryl group (-SH) on one chain end. The free thiol groups react readily with maleimido or iodacetamido functionalities or transition metal surfaces like gold, silver etc. Reaction with other free thiols leads to S-S disulfide bonds which can be cleaved by reducing agents. PEG thiols may also be conjugated by thiol-ene chemistry. Carboxy PEGs may be used for conjugation to amine substrates (forming amides) or other nucleophiles (forming esters). However, activation is necessary prior to conjugation. Different PEG carboxy derivatives display a different degree of stability and reactivity of the corresponding active ester.

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