Name: Bulk anti-Human HLA-DR antibody (L243) - Low Endotoxin
Price: 680.00 USD

- Overview
  - Antigen Distribution: The HLA-DR antigen is present on B-lymphocytes, activated T-lymphocytes and activated natural killer (NK) lymphocytes. This antigen is also expressed on monocytes, macrophages, human progenitor cells and B-cell lymphomas.
    Specificity: Anti-HLA-DR In Vivo Antibody - Low Endotoxin (L243) recognizes/reacts with the HLA-DR antigen, a member of MHC class II molecules. It does not cross-react with HLA-DP and HLA-DQ
    Purification method: This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
    Isotype Control: Mouse IgG2a In Vivo Isotype Control - Low Endotoxin [C1.18.4] (ICH2245)
    Endotoxin: ≤ 1.0 EU/mg as determined by the LAL method
    Aggregation: Aggregation level ≤ 5%
    
    Please contact us at for specific academic pricing.
    
    Background
    
    HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kD (heavy) chain & a 27 kD (light) chain. It is expressed on B cells, activated T cells, monocytes/macrophages, and dendritic cells. HLA-DR is critical for efficient peptide presentation to CD4+ T cells. Clone L243 binds a conformational epitope on HLA-DRalpha which depends on the correct folding of the Aβ heterodimer.
- Properties
  - Host
    
    mouse
    
    Isotype
    
    IgG2a
    
    Reactivity
    
    human
    
    Clone
    
    L243
    
    Immunogen
    
    Unknown
    
    Purification
    
    >95% by SDS-PAGE and HPLC
    
    Formulation
    
    No carrier proteins or preservatives added in 0.01 M phosphate buffered saline (PBS) pH 7.2 - 7.4.
    
    Storage
    
    anti-HLA-DR In Vivo Antibody - Low Endotoxin (L243) is stable for at least four (4) weeks when stored at 2-8°C. For long-term storage, aliquot in working volumes without diluting and store at – 20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
    
    Molecular Weight
    
    1.0 mg/ml
    
    Regulatory Status
    
    Each investigator should determine their own optimal working dilution for specific applications.
    
    Antigen
    
    (Gene ID:Major Histocompatibility Class II, MHC class II, HLA-DR Monomorphic)
    
    * Products are for research use only. Not for use in diagnostic or therapeutic procedures.
- Applications
  - Application
    
    WB; Blocking; Flow Cytometry; Immunoprecipitation; CyTOF; IHC (frozen)
- Reference
  - WNT4 promotes macrophage polarization via
    granulosa cell M-CSF and reduces granulosa cell
    apoptosis in endometriosis

Bulk anti-Human HLA-DR antibody (L243) - Low Endotoxin

Bulk anti-Human HLA-DR antibody (L243) - Low Endotoxin

Background

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