Name: Bromocriptine mesylate
Price: 180.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Bromocriptine Mesylate is a potent, selective D2-like dopamine receptor agonist with pKi of 8.05±0.2. Depending on the D2-like dopamine receptor of the target tissue that Bromocriptine Mesylate binds to, it can decrease metabolic processes leading to glucose intolerance and insulin resistance, inhibit the release of pituitary prolactin, and stimulate motor activity in Parkinson's disease. Bromocriptine Mesylate has been approved for treatment of type 2 diabetes, pituitary prolactinomas, acromegaly and Parkinson's disease.
    
    1. Gardner B, Strange PG. Agonist action at D2(long) dopamine receptors: ligand binding and functional assays. British Journal of Pharmacology, 1998, 124(5): 978-984.
    2. Ozery M, Wadhwa R. Bromocriptine. [Updated 2021 May 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan.
    3. Seo EJ, Sugimoto Y, Greten HJ, et al. Repurposing of Bromocriptine for Cancer Therapy. Frontiers in pharmacology, 2018, 9: 1030.
    4. Harish Kumar VS, Vinutha MB, Pradeep AN, et al. Bromocriptine, a Dopamine (d2) Receptor Agonist, Used Alone and in Combination with Glipizide in Sub-Therapeutic Doses to Ameliorate Hyperglycaemia. Journal of clinical and diagnostic research, 2013, 7(9): 1904-1907.
- Properties
  - Categories
    
    A potent, selective D2-like dopamine receptor agonist
    
    Alternative Name
    
    (6aR,9R)-5-bromo-N-((2R,5S,10aS,10bS)-10b-hydroxy-5-isobutyl-2-isopropyl-3,6-dioxooctahydro-2H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide methanesulfonate
    
    CAS Number
    
    22260-51-1
    
    Molecular Formula
    
    C32H40BrN5O5·CH3SO3H
    
    Molecular Weight
    
    750.7
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; insoluble in EtOH; ≥20.05 mg/mL in DMSO
    
    Storage
    
    Store at RT
    
    SMILES
    
    BrC(NC1=CC=CC2=C31)=C3C[[email protected]](C2=C4)N(C)C[[email protected]@H]4C(N[[email protected]]5(C(C)C)O[[email protected]@]6(N(C5=O)[[email protected]@H](CC(C)C)C(N7[[email protected]]6CCC7)=O)O)=O.OS(=O)(C)=O
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Bromocriptine mesylate

Bromocriptine mesylate

Background

Documents

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