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Overview
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Background
BRD4770 is a histone methyltransferase G9a inhibitor with an IC50 of 6.3 μM and induces cell death[1].
In pancreatic cancer cell line PANC-1, BRD4770 reduces intracellular di- and trimethylated H3K9 levels through inhibition of G9a, induces senescence, and inhibits adherent-dependent and independent proliferation[1].
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