Brassinolide

- Overview
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    Background
    
    IC50: N/ABrassinolide is a plant growth regulator. Plant growth regulators are naturally produced by plants and are critical for regulating their own growth. Plant growth regulators act via modifying or controlling plant growth processes, such as leave and flower formation, stem elongation, as well as fruit development and ripening.In vitro: Brassinolide induced the time and concentration-dependent cytotoxicity in PC-3 cells. The mode of such cell death appeared to be apoptosis predominately, as demonstrated by fluorescence, flow-cytometric analyses and transmission electron microscopes. Moreover, Caspase-3 activity was increased after brassinolide treatment obviously. Western blot studies showed brassinolide treatment triggered a time-dependent decrease in the expression of Bcl-2 [1]. In vivo: Brassinolide had the similar function of reducing the blood glucose levels as phenformin, but without the dose-dependent manner. The blood glucose levels showed significant differences after brassinolide treatment with different doses (200, 100, and 50 mg/kg). These results indicated that brassinolide could reduce the blood glucose levels without toxicity [2]. Clinical trial: So far, no clinical study has been reported.
    
    [1] Wu YD,Lou YJ. Brassinolide, a plant sterol from pollen of Brassica napus L., induces apoptosis in human prostate cancer PC-3 cells. Pharmazie.2007 May;62(5):392-5.
    [2] CHEN Shi-ping, HE Jia, WANG Qi-jing, WANG Jian-dong, YE Yan-li, XIAN Li-jian. Effect of Brassinolide on Levels of Blood Glucose in Alloxan—induced Diabetes Rats. Acta Metallurgica Sinica, 2009,V26(03): 21-23
- Properties
  - Categories
    
    Plant growth regulator
    
    Alternative Name
    
    24-Epibrassinolide,Brassin lactone; (3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-((2S,3R,4R,5S)-3,4-dihydroxy-5,6-dimethylheptan-2-yl)-5,6-dihydroxy-7a,9a-dimethyltetradecahydro-1H-benzo[c]indeno[5,4-e]oxepin-3(12bH)-one
    
    CAS Number
    
    72962-43-7
    
    Molecular Formula
    
    C28H48O6
    
    Molecular Weight
    
    480.68
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥48.1 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥52.3 mg/mL in EtOH with gentle warming and ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC(C)[[email protected]](C)[[email protected]@H](O)[[email protected]](O)[[email protected]@H](C)[[email protected]@]1([H])CC[[email protected]@]2([H])[[email protected]]3([H])COC([[email protected]@]4([H])C[[email protected]](O)[[email protected]](O)C[[email protected]]4(C)[[email protected]@]3([H])CC[[email protected]@]21C)=O
    
    * For Research Use Only