Boc-Lys(Ac)-AMC

- Overview
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    Background
    
    Commendamide (N-acyl-3-hydroxypalmitoyl-glycine) is a newly discovered GPCR G2A/GPR132 agonist (EC50=11.8 μM) that isolated from Bacteroides vulgatus. [1]
    G2A/GPR132 belongs to the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. GPR132/G2A is first reported to be a transcriptional target for BCR-ABL tyrosine kinase attenuating B-cell expansion in vitro and arresting cells at G2 during mitosis. It has been involved in autoimmune disease and atherosclerosis. [1]
    Commendamide and structurally related endogenous long-chain N-Acyl-amides activates discrete human receptors. In a screen for agonist activity against a library of 242 GPCRs, commendamide is found to activate a single receptor G2A/GPR132. This activity is confirmed by a synthetic sample of commendamide. Commendamide analogs with changes in the head group or acyl chain also exhibited reduced GPR132/G2A activity. [1]
- Properties
  - Categories
    
    GPCR G2A/GPR132 agonist
    
    Alternative Name
    
    (S)-tert-butyl (6-acetamido-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxohexan-2-yl)carbamate
    
    CAS Number
    
    233691-67-3
    
    Molecular Formula
    
    C23H31N3O6
    
    Molecular Weight
    
    445.51
    
    Appearance
    
    A solid
    
    Purity
    
    99.23%
    
    Solubility
    
    insoluble in H2O; ≥10.26 mg/mL in EtOH; ≥16.2 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC(C)(C)OC(N[[email protected]](C(NC(C=C1)=CC(O2)=C1C(C)=CC2=O)=O)CCCCNC(C)=O)=O
    
    * For Research Use Only
- Reference
  - 1. Mark K. Adams, Charles A.S. Banks, et al. "Differential complex formation via paralogs in the human Sin3 protein interaction network." bioRxiv. 2019 November 04.
    2. Banks CAS, Miah S, et al. "Differential HDAC1/2 network analysis reveals a role for prefoldin/CCT in HDAC1/2 complex assembly." Sci Rep. 2018 Sep 12;8(1):13712. PMID:30209338