Name: BMX-IN-1
Price: 496.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    BMX-IN-1 is a highly selective and irreversible inhibitor of BMX kinase [1].BMX, also known as ETK, is a member of Tec family and plays an important role in regulating ischemia-mediated arteriogenesis and lymphangiogenesis. BMX is mainly expressed in arterial endothelia and in myeloid hematopoietic cells and it has been reported that BMX involves in tumor growth [2].BMX-IN-1 is a potent BMX kinase inhibitor and has an irreversible function on BMX kinase. When tested with prostate cancer cell lines, BMX-IN-1 treatment inhibited the proliferation of Tel-BMX-transformed Ba/F3 cells at lowdose [1].
    
    [1].Liu, F., et al., Discovery of a selective irreversible BMX inhibitor for prostate cancer. ACS Chem Biol, 2013. 8(7): p. 1423-8.
    [2].Holopainen, T., et al., Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth. Cancer Res, 2012. 72(14): p. 3512-21.
- Properties
  - Alternative Name
    
    BMX kinase inhibitor; N-[5-[9-[4-(methanesulfonamido)phenyl]-2-oxobenzo[h][1,6]naphthyridin-1-yl]-2-methylphenyl]prop-2-enamide
    
    CAS Number
    
    1431525-23-3
    
    Molecular Formula
    
    C29H24N4O4S
    
    Molecular Weight
    
    524.59
    
    Appearance
    
    A solid
    
    Purity
    
    98.20%
    
    Solubility
    
    insoluble in H2O; insoluble in EtOH; ≥5.25 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

BMX-IN-1

BMX-IN-1

Background

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