Name: BMS 193885
Price: 620.00 USD

- Overview
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    Background
    
    BMS-193885 is a potent and selective neuropeptide Y1 receptor antagonist with IC50 of 5.9nM.
    Neuropeptide Y receptor 1 is G-protein coupled receptors and implicated in the modulation of food intake and energy homeostasis. Neuropeptide Y1 is expressed in many tissues including the hippocampus, hypothalamus, amygdala and the cortex of the brain as well as in peripheral tissues heart, kidney, skeletal muscle. The localization and expression suggests their involvement in the regulation of food intake and body weight.
    In cellular culture, BMS-193885 displayed functional antagonism of Neuropeptide Y1 in a
    forskolin-stimulated c-AMP production assay using CHO cells expressing the human Y(1) receptor 1.
    In vivo, administration of BMS-193885 at a dosage of 10mg/kg leads to 1h neuropeptide Y-induced food intake in rat and the spontaneous overnight food consumpetion 2 . Chronic administration of BMS-193885 (10 mg/kg) i.p. for 44 days significantly reduced food intake and the rate of body weight gain as compared to their control without developing tolerance or affecting water intake 2.
    
    1. Poindexter GS, Bruce MA, LeBoulluec KL, et al. Dihydropyridine neuropeptide Y Y(1) receptor antagonists. Bioorganic & medicinal chemistry letters. 2002;12(3):379-382.
    2. Antal-Zimanyi I, Bruce MA, Leboulluec KL, et al. Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y(1) receptor antagonist. European journal of pharmacology. 2008;590(1-3):224-232.
- Properties
  - Categories
    
    Competitive NPY Y1 receptor antagonist
    
    Alternative Name
    
    (S)-2-hydroxypropanoic acid compound with (Z)-N-(3-(3,5-bis(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridin-4-yl)phenyl)-N'-(3-(4-(3-methoxyphenyl)piperidin-1-yl)propyl)carbamimidic acid (1:1)
    
    CAS Number
    
    679839-66-8
    
    Molecular Formula
    
    C33H42N4O6·C3H6O3
    
    Molecular Weight
    
    680.79
    
    Appearance
    
    Pale yellow solid
    
    Purity
    
    98.00%
    
    Solubility
    
    <68.08mg/ml in DMSO; <13.62mg/ml in H2O
    
    Storage
    
    Desiccate at RT
    
    SMILES
    
    CC(N1)=C(C(OC)=O)C(C(C(OC)=O)=C1C)C2=CC(N/C(O)=N/CCCN3CCC(C4=CC(OC)=CC=C4)CC3)=CC=C2.C[[email protected]@](O)([H])C(O)=O
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

BMS 193885

BMS 193885

Background

Documents

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