Bis(12-crown-4)

- Overview
  - The NAS11-8 glass electrode is utilized as a selective sodium ion sensor. However, it is easily spoiled by biomaterials in sample solutions. Bis(12-crown-4), a sodium ionophore, is 100 times more selective for sodium than potassium in the PVC electrode using NPOE as a plasticizer. The same selectivity for sodium over potassium is reported when Bis(12-crown-4) is used on a coated wire electrode. It can be used in either a liquid membrane or a PVC membrane. TFPB, a lipophilic anion, can help improve detection sensitivity.
    
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- Properties
  - Categories
    
    Ion Analysis
    
    CAS Number
    
    80403-59-4
    
    Molecular Formula
    
    C34H62O12
    
    Molecular Weight
    
    662.85
    
    Appearance
    
    pale yellow liquid
    
    Purity
    
    ≥95.0% (HPLC; RI)
    
    Storage
    
    ambient temperature
    
    Shipping
    
    ambient temperature
    
    * For research use only
- Reference
  - 1) I. Ikeda, et al., Syntheses of Ester-type Bis-12-crown-4 Ethers and Their Complexing Abilities toward Sodium Cation. Tetrahedron Lett. 1981;22:3615-3616.
    
    2) H. Tamura, et al., Coated Wire Sodium- and Potassium-selective Electrodes Based on Bis(crown ether) Compounds. Anal Chem. 1982;54:1224-1227.
    
    3) T. Shono, et al., Sodium-selective PVC Membrane Electrodes Based on Bis(12-crown-4)s. J Electroanal Chem. 1982;132:99-105.
    
    4) H. Tamura, et al., Simultaneous Determination of Sodium and Potassium in Human Urine or Serum Using Coated-wire Ion-selective Electrodes Based on Bis(crown ether)s. Mikrochim Acta. 1983;80:287-296.
    
    5) H. Sakamoto, et al., Lipophilic Bis(monoaza crown ether) Derivatives: Synthesis and Cation-complexing Properties. J Org Chem. 1986;51:4974-4979.
    
    6) T. Maruizumi, et al., Neutral Carrier-based Na+ -selective Electrode for Application in Blood Serum. Mikrochim Acta. 1986;1:331-336.
    
    7) N. Nakashima, et al., Design of a Novel Bilayer System Responsive to Chemical Signals; Selective Discrimination of Na+ by a Spectroscopic Method. J Chem Soc Chem Commun. 1987:617-619.
    
    8) H. Widmer, et al., The Increase of Oxygen Consumption after a Flash of Light Is Tighly Coupled to Sodium Pumping in the Lateral Ocellus of Barnacle. J Gen Physiol. 1990;96:83-108.
    
    9) M. Tanaka, et al., Evaluation of Complex Formation of Bis(12-crown-4)s with Sodium Picrate in Solution by 23Na NMR Spectroscopy. Chem Lett. 1990;19:1419-1422.
    
    10) Y. Shibutani, et al., Chiral Bis(12-crown-4)-based Electrodes for Sodium Ion. Chem Lett. 1997;26:49-50.

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