Bis-dPEG®₁₁-DBCO

Bis-dPEG®11-DBCO, product number 11372, is a click chemistry reagent consisting of two dibenzylcyclooctyne (DBCO) groups separated by a single molecular weight, discrete polyethylene glycol (dPEG®) spacer. The DBCO groups react with azide groups via the bioorthogonal click chemistry reaction known as strain-promoted azide-alkyne cycloaddition (SPAAC), also known as copper-free click chemistry. This product is particularly useful for click chemistry reactions where the presence or use of copper(I) [Cu(I)] is undesirable.

Traditional polyethylene glycol (PEG) is a dispersed polymer consisting of a complex Poisson distribution of different chain lengths and molecular weights that make exact analysis and characterization quite challenging. Our dPEG® products contain precisely defined, single molecular weight, discrete PEG chains (thus the dPEG® trademark). Discrete PEG reagents provide all of the benefits of traditional PEG, including water solubility, increased hydrodynamic volume with consequent protection from renal clearance, reduced or eliminated aggregation, and reduced or eliminated immunogenicity. Discrete PEG reagents also remove the analytical complications that result from the presence of an often-large distribution of PEG oligomers found in traditional polymer PEG reagents.

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