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Overview
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Thioredoxin (TXN) is a small ubiquitous protein in all cells that plays an important role in cellular redox reactions. It is secreted by lymphocytes, hepatocytes, fibroblasts, and several tumor cells. TXN is up-regulated under stress conditions such as hypoxia, elevated hydrogen peroxide concentrations, photochemical oxidative stress, and viral and bacterial infections. TXN modulates the growth factor activities, and the antioxidant properties, as well as act as a cofactor that provides reducing equivalents, and transcriptional regulation.
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