BIOMIMESYS® Liver 96/384 well-plate format

BIOMIMESYS® is a unique groundbreaking 3D cell culture technology which associates the behavior of a solid scaffold and of a hydrogel. It provides a cell culture microenvironment reproducing all aspects of human tissues, including matrix architecture, cellular organization, cell-cell and cell-matrix interactions.
Depending on the organ, extracellular matrix components and their proportions may vary, allowing a more or less dense and compact cellular environment (different Elastic Moduli, porosities).
BIOMIMESYS® matrices are made of Hyaluronic Acid (HA), the main glycosaminoglycan (GAG) of the ECM, collagens and adhesion proteins. Our patented manufacturing process allows to preserve the natural properties of HA and therefore synthesizing proprietary Hydroscaffold™.

Tuning the composition of BIOMIMESYS® matrix allows to mimic the cellular microenvironment of any organ or tissue of interest.

Composition
BIOMIMESYS®Liver scaffold is made of RGDSgrafted Hyaluronic acid (HA-g-RGDS) (1.6 MDa), galactosamine-grafted Hyaluronic acid (HA-gGalN), Adipic acid dihydrazide crosslinker (ADH) and extracellular matrix (ECM) proteins (collagen type I and collagen type IV).

Cells already tested
Primary human cells: Primary hepatocytes
Cell lines:
Hepatocytes : HepG2/HepaRG
Stellate: LX2
iPSC-derived human liver organoids or hepatocytes

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