Name: BIM 23042
Price: 421.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Ki: 49 ±14 nM for neuromedin B-induced endpoint in huNMBR cells
    Neuromedin B, a mammalian peptide of the bombesinlike peptide family sharing amino acid homology with its amphibian counterpart ranatensin, elicits a diverse array of biological responses in central and peripheral tissues. BIM 23042 [D-Nal-Cys-Tyr- D-Trp-Lys-Val-Cys-Nal-NH2] is a selective neuromedin B antagonist.
    In vitro: BIM 23042 has a l00-fold greater affinity for BB1 receptors than BB2 receptors. The submaximal mobilisation observed with neuromedin B (1 nM) was abolished by BIM 23042 but restored with a subsequently higher concentration of neuromedin B (1 μM). BIM 23042 competitively inhibited neuromedin B-induced endpoint in huNMBR cells with a Ki of 49 ±14 nM [1].
    Clinical trial: Up to now, BIM 23042 is still in the preclinical development stage.
    
    [1] Ryan RR, Taylor JE, Daniel JL, Cowan A. Pharmacological profiles of two bombesin analogues in cells transfected with human neuromedin B receptors. Eur J Pharmacol. 1996 Jun 13;306(1-3):307-14.
- Properties
  - Categories
    
    Antagonist of neuromedin B receptor, selective
    
    CAS Number
    
    111857-96-6
    
    Molecular Formula
    
    C62H73N11O9S2
    
    Molecular Weight
    
    1180.44
    
    Appearance
    
    White lyophilised solid
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble to 1 mg/ml in 0.1% acetic acid
    
    Storage
    
    Desiccate at -20°C
    
    SMILES
    
    CC([[email protected]@](/N=C(O)/[[email protected]](/N=C(O)/[[email protected]@](/N=C(O)/[[email protected]](/N=C(O)/[[email protected]](/N=C(O)/[[email protected]@](N)([H])C1=CC2=CC=CC=C2C=C1)([H])CS)([H])CC3=CC=C(O)C=C3)([H])CC4=CNC5=CC=CC=C45)([H])CCCCN)([H])/C(O)=N/[[email protected]@](/C(O)=N/[[email protected]@](C(O)=N)([H])CC6=CC7=CC=CC=C7C=C6)([H])CS)C
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

BIM 23042

BIM 23042

Background

Documents

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