Bile Acid Receptor - ExpressMAX™ Human GPCR ORF Clones

Bile Acid Receptor - ExpressMAX™ Human GPCR ORF Clones

Catalog Number:
MEV1268640CAN
Mfr. No.:
G0512-B; G0512-Plus
Price:
$575
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      • Overview
        • Bile Acid GPCR (GPBAR1) functions as a cell surface Receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway and internalization of the Receptor. The Receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in three transcript variants encoding the same protein.

          Includes:
          ExpressMAX™ GPCR ORF Clones (Cat. No. – B)
          – Vector as transformed Bacteria in stab culture or a Glycerol Stock format.
          Mammalian Transfection Kits (Cat. No. – PLUS)
          – 15 µg ExpressMAX™ Mammalian Expression Vector (1 mg/mL).
          – 0. 2 mL CANFAST™ Transfection Reagent.

          Please contact us at for specific academic pricing.

      • Properties
        • Categories
          Human GPCR ORF Clones
          Other Properties
          Plasmid size: 6332 bp
          Promoter: pMLV
          ORF Sequence (GenBank based): NM_170699
          Protein Sequence (SwissProt): Q8TDU6
          Bacterial Selection Antibiotics: Ampicillin
          Mammalian Selection Antibiotic: Neomycin
          Alternative names: BG37, TGR5, M-BAR or GPCR19
          Storage
          ExpressMAX™ GPCR ORF Clones (-20 °C) and CANFAST™ (4 °C).

          * This product is developed, designed and sold exclusively for Research purposes and in vitro use only (RUO). The product was not tested for use in diagnostics or for drug development, nor is it suitable for administration to humans or animals.

      • Applications
        • Application Description
          Functional assays, as protein immobilization, cellular localization and other functional assays.
          High-throughput and large scale protein production and purification.
          Reverse transfection arrays and nucleic acid programmable protein arrays (NAPPA).

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