Beta-Cell Activating Factor ELISA (BAFF ELISA)

BAFF (B cell activating factor belonging to the TNF family, also known as BLyS or TALL1) is a cytokine expressed predominantly by cells of the immune system such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells, activated T cells and some malignant B cells. BAFF binds three distinct receptors (BAFFR, TACI and BCMA) predominantly expressed on B cells, although activated T cells also express BAFFR. BAFF is a master regulator of peripheral B cell survival, and also acts in processes such as immunoglobulin isotype switch and B cell co-stimulation. Beside its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of this membrane-bound protein, which can readily be released in a soluble form by proteolytic cleavage, leads to autoimmune disorders in mice. In the human, elevated levels of soluble BAFF have been detected in the serum of individuals with various autoimmune diseases, such as rheumatoid arthritis (RA), Sjögren syndrome (SS) and systemic lupus erythematosus (SLE). BAFF levels are also elevated in individuals with multiple myeloma and B-cell chronic lymphoid leukemia (B-CCL).
The Beta-Cell Activating Factor ELISA (BAFF ELISA) is for Research Use Only. The Beta-Cell Activating Factor ELISA (BAFF ELISA) is not for use in diagnostic procedures.

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