Name: Bax inhibitor peptide P5
Price: 292.00 USD

- Overview
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    Background
    
    Bax inhibitor peptide P5 (BIP P5) is a peptide inhibitor of Bax translocation to mitochondria [1].
    Bax is a pro-apoptotic member of Bcl-2 family proteins and plays an important role in mitochondria-dependent apoptosis. Bax stays in the cytosol and transfers into mitochondria after apoptotic stimuli [1].
    BIP P5 is a membrane-permeable peptide inhibitor of Bax translocation to mitochondria. In HeLa cells, BIP P5 protected cells from UVC- and STS-induced apoptosis. In U87-MG glioma cells, MCF-7 breast cancer cells and LNCaP prostate cancer cells, BIP P5 also inhibited apoptosis induced by anti-cancer drugs cisplatin, etoposide and doxorubicin. While BIP P5 did not suppress UVC- or STS-induced apoptosis in Bax-deficient cells (DU145), which suggested BIP P5 only suppressed Bax-mediated apoptosis. The caspase activation and the release of cytochrome c from mitochondria triggered by apoptotic stimuli were also significantly inhibited by BIP P5. BIP P5 inhibited the interaction of Ku70 and endogenous Bax in a dose-dependent way [1].
- Properties
  - Alternative Name
    
    (2S)-2-[[(2S)-6-amino-2-[[(2S)-4-methyl-2-[[(2S)-4-methylsulfanyl-2-[[(2S)-pyrrolidine-2-carbonyl]amino]butanoyl]amino]pentanoyl]amino]hexanoyl]amino]pentanedioic acid
    
    CAS Number
    
    579492-83-4
    
    Molecular Formula
    
    C27H48N6O8S
    
    Molecular Weight
    
    616.77
    
    Appearance
    
    A solid
    
    Purity
    
    99.59%
    
    Solubility
    
    ≥61.7 mg/mL in DMSO; ≥101 mg/mL in EtOH with ultrasonic; ≥94.4 mg/mL in H2O
    
    Storage
    
    Desiccate at -20°C
    
    * For Research Use Only

Bax inhibitor peptide P5

Bax inhibitor peptide P5

Background

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