BAD(Phospho-Ser112) Antibody

BAD(Phospho-Ser112) Antibody

Catalog Number:
A001548095RED
Mfr. No.:
RDSA62070
Price:
$483
  • Size:
    100μL
    Quantity:
    Add to Cart:
      • Overview
        • Please contact us at for specific academic pricing.

          Background

          The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

      • Properties
        • Host
          rabbit
          Antibody Type
          polyclonal
          Isotype
          IgG
          Reactivity
          human; mouse
          Immunogen
          Peptide sequence around phosphorylation site of serine 112 (H-S-S(p)-Y-P) derived from Mouse BAD.
          Purification
          Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatography using non-phosphopeptide.
          Conjugate
          Unconjugated
          Formulation
          Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
          Storage
          Store at -20°C. Avoid freeze / thaw cycles.
          Concentration
          1.0 mg/mL
          Molecular Weight
          23kDa (Observed)
          Antigen
          Bbc2 (Gene ID:12015; UniProt:Q61337)

          * This product is for Research Use Only.

      • Applications
        • Application
          WB; IHC
        • Application Dilutions
          WB 1:500-1:1000
          IHC 1:50-1:100

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