Name: AZD3264
Price: 290.00 USD

- Overview
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    Background
    
    Target: IKK2IC50: N/AAZD3264 is a novel and small molecule IKK2 inhibitor.IKK2 serves as a protein subunit of IκB kinase, which is a component of the cytokine-activated intracellular signaling pathway involved in triggering immune responses. IKK's activity induces the activation of a transcription factor NF-κB. Activated IKK2 phosphorylates IκB (IκBα), which binds NF-κB to inhibit its function. Phosphorylated IκB is degraded by the ubiquitination pathway, freeing NF-κB, and allowing its entry into the cell nucleus where it activates target genes involved in inflammation and other immune responses. Suppression of IKK2 has been identified as a potential therapeutic option to treat cancer and inflammatory diseases, including asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis [1].In vitro: AZD3264, by inhibiting IKK2, was currently in preclinical development for the potential treatment of inflammatory diseases such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis [2].In vivo: N/A
    
    1. Llona-Minguez S, Baiget J, Mackay SP. Small-molecule inhibitors of IkappaB kinase (IKK) and IKK-related kinases. Pharm Pat Anal. 2013;2(4):481-98. 2. Murugan A, et al. Org. Process Res. Dev. 2014, 18, 646-651.
- Properties
  - Alternative Name
    
    (S)-5-(4-(3,5-dimethylisoxazol-4-yl)-2-(pyrrolidin-3-yloxy)phenyl)-2-ureidothiophene-3-carboxamide
    
    CAS Number
    
    1609281-86-8
    
    Molecular Formula
    
    C21H23N5O4S
    
    Molecular Weight
    
    441.5
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; insoluble in EtOH; ≥24.95 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

AZD3264

AZD3264

Background

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