Name: AVE 0991
Price: 483.00 USD

- Overview
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    Background
    
    AVE 0991 is an agonist of angiotensin-(1-7) receptor [1].As an ang-(1–7) mimic, AVE0991 acts as a nonpeptide agonist of angiotensin-(1-7) receptor. In water-loaded mice (C57BL/6), AVE0991(0.58 nmol/g)produces a significant decrease of water dieresis. The antidiuretic effect of AVE was associated with an increase in urine osmolality. It also occurs in water-loaded Swiss mice. The antidiuretic action of AVE can be blocked by the Ang II antagonists completely, demonstrating the specificity of AVE 0991. Since Ang II promotes atherogenesis and ang-(1–7) opposites Ang II action, it is reported that AVE 0991 can inhibit atherogenesis in apolipoprotein E (apoE)-knockout mice model [1, 2].
    
    [1] Sergio Veloso Brant Pinheiro, Ana Cristina Simoes e Silva, Walkyria Oliveira Sampaio, Renata Dutra de Paula, Elizabeth Pereira Mendes, Elizabete Dias Bontempo, Joao Bosco Pesquero, Thomas Walther, Natalia Alenina, Michael Bader, Markus Bleich, Robson Augusto Souza Santos. Nonpeptide AVE 0991 Is an Angiotensin-(1–7) Receptor Mas Agonist in the Mouse Kidney. Hypertension. 2004, 44: 490-496.
    [2] J. Toton-Zuranska, M. Gajda, G. Pyka-Fosciak, K. Kus, M. Pawlowska, A. Niepsuj, P. Wolkow, R. Olszanecki, J. Jawien, R. Korbut. AVE 0991- angiotensin-(1-7) receptor agonist, inhibits atherogenesis in APOE-knockout mice. Journal of physiology and pharmacology. 2010, 61(2):181-183.
- Properties
  - Categories
    
    Agonist of angiotensin-(1-7) receptor
    
    Alternative Name
    
    1-ethyl-3-[3-[4-[(5-formyl-4-methoxy-2-phenylimidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylurea
    
    CAS Number
    
    304462-19-9
    
    Molecular Formula
    
    C29H32N4O5S2
    
    Molecular Weight
    
    580.72
    
    Appearance
    
    A solid
    
    Purity
    
    99.31%
    
    Solubility
    
    ≥29.04 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CCNC(=O)NS(=O)(=O)C1=C(C=C(S1)CC(C)C)C2=CC=C(C=C2)CN3C(=C(N=C3C4=CC=CC=C4)OC)C=O
    
    * For Research Use Only
- Reference
  - 1. Sanket Patel, Tahir Hussain, et al. "Synergism between Angiotensin receptors ligands: Role of Angiotensin‐(1‐7) in modulating AT2R agonist response on nitric oxide in kidney cells." Pharmacol Res Perspect. 2020 Dec;8(6):e00667. PMID:33197136
    2. Ming Zhang, Xintao Zhu, et al. "AVE 0991 Attenuates Pyroptosis and Liver Damage after Heatstroke by Inhibiting the ROS-NLRP3 Inflammatory Signalling Pathway." BioMed Research International. Volume 2019, Article ID 1806234, 12 pages.
    3. Foulquier S, Caolo V, et al. "The role of receptor MAS in microglia-driven retinal vascular development." Angiogenesis. 2019 Jun 20. PMID:31240418
    4. Burghi V, Echeverría EB, et al. "Participation of Gα(i)-Adenylate Cyclase and ERK1/2 in Mas Receptor Signaling Pathways." Front Pharmacol. 2019 Feb 22;10:146. PMID:30853914