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Overview
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Adenosine triphosphate (ATP) is an energy source for living cells and is synthesized by both glycolysis and mitochondrial oxidative phosphorylation. Mitochondria generate 95% of cellular ATP, and mitochondrial dysfunction reduces ATP levels in cells. Therefore, the measurement of ATP levels has been established as a proxy for mitochondrial activity. Decreased ATP levels are associated with cancer, aging, neurodegenerative diseases, and mitochondrial diseases.
Cancer cells rely on glycolysis, a process that is less efficient than oxidative phosphorylation to synthesize ATP. However, recent studies have revealed that ATP synthesis in cancer cells shifts from glycolysis to oxidative phosphorylation when glycolysis is suppressed. The ATP Assay Kit-Luminescence enables the quantitation of intracellular ATP by luciferase luminescence assay. This kit can be applied for microplate assay.Please contact us at for specific academic pricing.
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Overview