Name: ATB-346
Price: 515.00 USD

- Overview
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    Background
    
    ATB-346 is a hydrogen sulphide-releasing anti-inflammatory drug [1].ATB-346 is a non-steroidal anti-inflammatory drug (NSAID) and shows a markedly reduced toxicity than its parent compound naproxen. In the airpouch model, ATB-346 significantly inhibited the PGE2 level and completely suppressed the whole blood TXB2 synthesis without causing gastric damage. In rats with adjuvant-Induced arthritis, administration of ATB-346 reduced the paw volume on days 14 and 21 notably. ATB-346 did not exert any damage or bleeding in the stomach or small intestine while naproxen caused bleeding in the small intestine. Besides that, administration of naproxen twice daily for 5 days in rats resulted in extensive damage in the small intestine. In contrast, same dose of ATB-346 caused quite little damage over the treatment of the 5 days [1].
    
    [1] Wallace J L, Caliendo G, Santagada V, et al. Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346). British journal of pharmacology, 2010, 159(6): 1236-1246.
- Properties
  - Categories
    
    Non-steroidal anti-inflammatory drug
    
    Alternative Name
    
    4-carbamothioylphenyl 2-(6-methoxynaphthalen-2-yl)propanoate
    
    CAS Number
    
    1226895-20-0
    
    Molecular Formula
    
    C21H19NO3S
    
    Molecular Weight
    
    365.45
    
    Appearance
    
    A solid
    
    Purity
    
    98.60%
    
    Solubility
    
    insoluble in EtOH; insoluble in H2O; ≥18.27 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    COC1=CC=C2C(C=CC(C(C)C(OC3=CC=C(C(N)=S)C=C3)=O)=C2)=C1
    
    * For Research Use Only