Name: Apremilast- Bio-X
Price: Inquiry

- Overview
  - Apremilast is the commercial name of a phosphodiesterase4 (PDE4) inhibitor developed to treat chronic inflammatory disorders. Similarly to thalidomide, the apremilast molecule carries a phthalimide ring, but it lacks however the glutarimide ring needed to bind to cereblon, specifically targeted by thalidomide. As a drug, apremilast is indicated for the treatment of psoriasis and psoriatic arthritis.
    
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- Properties
  - Categories
    
    Enzyme Modulators
    
    Alternative Name
    
    (S)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
    
    CAS Number
    
    608141-41-9
    
    Molecular Formula
    
    C22H24N2O7S
    
    Molecular Weight
    
    460.5 g/mol
    
    MDL Number
    
    MFCD18782607
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Schafer (2012). Apremilast mechanism of action and application to psoriasis and psoriatic arthritis. Biochemical Pharmacology, 83(12): 1583-1590.
    Schafer et al (2014). Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity. Cellular Signalling, 26(9): 2016-2029.