Name: APC Anti-Mouse Foxp3 Antibody
Price: 364.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2.
- Properties
  - Host
    
    mouse
    
    Antibody Type
    
    monoclonal
    
    Isotype
    
    IgG1 kappa
    
    Reactivity
    
    mouse
    
    Conjugate
    
    APC
    
    Formulation
    
    PBS with 0.05% Proclin300, 1% BSA
    
    Storage
    
    Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
    
    Antigen
    
    Forkhead box protein P3, IPEX, JM2, Foxp3 (Gene ID:50943,20371,317382; UniProt:Q99JB6)
    
    * For reference only.
- Applications
  - Application
    
    ICFCM