Antibody Deruxtecan High Loading Conjugation Kit

This kit is designed to label any antibody (IgG) with high amount of Deruxtecan. Trastuzumab Deruxtecan, sold under the brand name Enhertu, typically has an average of 8 molecules of Deruxtecan attached to each antibody molecule (Nakada, T. et al. Bioorg. Med. Chem. Lett. 2016, 26, 1542-1545). This kit is designed for loading approximately 8 Deruxtecan molecules per antibody. It is only recommended for use after performing conjugation with CM11431 (targeting 4 Deruxtecan per antibody) and confirming that significant aggregations or precipitations was not observed with your antibody using that kit.

The kit provides the materials to conjugate 1 to 3 mg of one antibody sample (CM11434x1) or three antibody samples (CM11434x3) of IgG with Deruxtecan, using enzymatic cleavable peptide linker, GGFG.

Drug Information
• Name: Deruxtecan (Mc-GGFG-DXd)
• Synonym: Exatecan derivative, DX 8951 derivative; DXd; payload for DS-8201a
• CAS number: 1599440-13-7
• Chemical formula: C52H56FN9O13
• MW: 1034.0684
• Mechanism of action: Trastuzumab Deruxtecan, sold under the brand name Enhertu was approved by US FDA for treating metastatic HER2-postive breast cancer.

Requirement for Antibody
• Preferably >90% pure by gel electrophoresis
• Total amount: 1-3 mg of protein content as measured by UV.

Key Features of this PerKit™
• Simple and efficient labeling of IgG with Deruxtecan, minimizing toxin exposure.
• Features enzymatic cleavable GGFG peptide linker.
• Delivers an average of 8 Deruxtecan molecules per antibody.
• Fast preparation: 4 hours total, with less than 1 hour of hands-on time.
• Includes all necessary reagents and supplies for preparation and purification.
• Achieves over 95% conjugation, free from unreacted drugs.
• Post-conjugation services are available from CellMosaic for analysis and DAR determination.

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